Elastin metabolic process

pathway activity — cross-omics
GO:0051541Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Elastin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3P33, SUMO2P13, and TSGA10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADH3P33 →-0.069-0.940.005<.00133
LSCCSUMO2P13 →-0.169-0.331.006<.00133
LUADTSGA10 →-0.535-0.470<.001.00133
BRCALRIF1 →+0.520+0.712.002.00232
BRCAIZUMO1R →-0.264-0.571.005.00332
CCRCCRN7SL146P →-0.456-0.844<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration