Elastin metabolic process

Across TCGA cell cohorts, RNA activity of the Elastin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGLY1, INA, and CTNNAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NGLY1 grouped by Elastin metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NGLY1 →	+0.892	+1.089	.001	.002	3	4
CNS	INA →	+1.747	+1.242	.001	<.001	3	4
OESOPHAGUS	CTNNAL1 →	+1.605	+1.190	<.001	<.001	2	4
OESOPHAGUS	MAP3K21 →	+1.077	+1.225	<.001	.001	3	3
OESOPHAGUS	LBR →	+0.838	+0.961	<.001	.007	3	3
PANCREAS	TFPT →	+1.089	+1.277	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NGLY1 by Elastin metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →