Positive regulation of stress fiber assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH12, ERG, and DLC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stress fiber assembly activity versus PCDH12 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDH12 →	+0.613	+0.184	<.001	.005	3	6
BRCA	ERG →	+0.700	+0.271	<.001	<.001	3	6
BRCA	DLC1 →	+0.664	+0.245	.001	<.001	3	6
CCRCC	JAM3 →	+0.743	+0.240	.003	.003	3	6
LSCC	CLEC14A →	+0.835	+0.615	<.001	<.001	3	6
LSCC	LIMCH1 →	+1.188	+0.320	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051496 vs PCDH12 — BRCA

Explore this scatter interactively →