Positive regulation of stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress fiber assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF1, RAC1, and CRKL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF1 grouped by Positive regulation of stress fiber assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAPGEF1 →	-0.595	-1.014	<.001	.005	3	8
STOMACH	RAC1 →	-0.558	-1.012	<.001	.002	3	7
LIVER	CRKL →	-0.628	-1.119	<.001	.008	3	6
LIVER	FERMT2 →	-0.509	-0.784	.001	.003	3	5
STOMACH	MTOR →	-0.661	-1.218	.001	.004	3	4
LIVER	TLN1 →	-0.514	-0.784	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF1 by Positive regulation of stress fiber assembly activity — LIVER

Explore this box plot interactively →