Positive regulation of stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT18, ERO1B, and TMCC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUDT18 grouped by Positive regulation of stress fiber assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NUDT18 →	+0.773	+1.281	.001	.001	3	4
BLOOD_Myeloma	ERO1B →	+2.160	+1.586	<.001	.002	3	4
LUNG_NSCLC_LUAD	TMCC2 →	+0.602	+0.640	.007	.004	3	4
BONE	MAP2 →	+2.020	+1.269	.002	<.001	3	4
BLOOD_Lymphoma	GM2A →	-1.782	-1.822	.004	<.001	2	5
STOMACH	CEBPB →	+1.067	+0.836	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUDT18 by Positive regulation of stress fiber assembly activity — KIDNEY

Explore this box plot interactively →