Positive regulation of stress fiber assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1B, ZNF837, and STOML1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stress fiber assembly activity versus POLR1B in OVARY (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	POLR1B →	-0.941	-0.353	.001	.001	2	6
LIVER	ZNF837 →	-1.079	-0.342	.004	.001	3	5
PANCREAS	STOML1 →	+0.865	+0.230	<.001	.001	3	5
BLOOD_Leukemia	CD47 →	+0.696	+0.240	.002	.009	3	5
LUNG_NSCLC_LUAD	JDP2 →	+1.518	+0.268	.001	<.001	3	5
OVARY	C1QBP →	-0.759	-0.208	.009	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051496 vs POLR1B — OVARY

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