Positive regulation of cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL10A, SEPTIN7, and SEPTIN8, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoskeleton organization activity versus RPL10A in OV (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL10A →	-0.289	-0.034	<.001	.002	3	9
UCEC	SEPTIN7 →	+0.287	+0.046	<.001	.003	3	9
BRCA	SEPTIN8 →	+0.403	+0.026	<.001	<.001	3	9
OV	SERBP1 →	-0.420	-0.048	<.001	<.001	3	9
OV	CNRIP1 →	+0.622	+0.038	.001	<.001	3	9
BRCA	MAP1B →	+0.542	+0.025	.008	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051495 vs RPL10A — OV

Explore this scatter interactively →