Positive regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTL8A, SLC16A7, and C19orf71, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RTL8A grouped by Positive regulation of cytoskeleton organization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RTL8A →	+3.324	+0.195	.003	.003	3	4
LIVER	SLC16A7 →	+2.348	+0.220	.004	.007	3	4
STOMACH	C19orf71 →	+0.551	+0.156	<.001	<.001	3	4
OESOPHAGUS	NHLRC1 →	+1.130	+0.192	.002	<.001	3	3
CNS	TYSND1 →	+0.797	+0.128	.002	.002	3	3
LARGE_INTESTINE	TPD52L2 →	+0.915	+0.152	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RTL8A by Positive regulation of cytoskeleton organization activity — BLOOD_Myeloma

Explore this box plot interactively →