Positive regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoskeleton organization pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKN2, POMK, and HUS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKN2 grouped by Positive regulation of cytoskeleton organization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PKN2 →	+0.146	+0.039	.002	.005	3	6
KIDNEY	POMK →	-0.196	-0.065	.005	.001	3	6
STOMACH	HUS1 →	-0.237	-0.064	.001	.001	3	6
BREAST	NDUFB7 →	-0.232	-0.057	.001	.001	3	5
BREAST	GFRA4 →	-0.212	-0.064	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SCAP →	-0.548	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKN2 by Positive regulation of cytoskeleton organization activity — BREAST

Explore this box plot interactively →