Positive regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDCD11, ARPC5, and ARHGAP1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoskeleton organization activity versus PDCD11 in CNS (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDCD11 →	-0.969	-0.195	<.001	<.001	3	15
LUNG_NSCLC_LUAD	ARPC5 →	+1.098	+0.208	<.001	<.001	3	14
BONE	ARHGAP1 →	+1.234	+0.295	<.001	<.001	3	14
OVARY	IMP3 →	-0.907	-0.240	<.001	<.001	3	14
URINARY_TRACT	ARPC3 →	+1.159	+0.258	.009	.001	3	13
BONE	DKC1 →	-0.635	-0.243	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051495 vs PDCD11 — CNS

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