Negative regulation of cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, SEPTIN4_S432, and TNS2_S102, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoskeleton organization activity versus SEPTIN4 in PDAC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEPTIN4 →	+0.568	+0.035	<.001	<.001	3	8
BRCA	SEPTIN4_S432 →	+0.613	+0.026	<.001	<.001	3	8
LSCC	TNS2_S102 →	+0.872	+0.042	<.001	<.001	3	8
BRCA	FERMT2 →	+0.613	+0.030	<.001	<.001	3	8
BRCA	SYNPO →	+0.365	+0.017	<.001	<.001	3	8
BRCA	TIMP2 →	+0.666	+0.020	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051494 vs SEPTIN4 — PDAC

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