Negative regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCF2L, FGD4, and RPSA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCF2L grouped by Negative regulation of cytoskeleton organization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MCF2L →	+2.738	+0.257	<.001	.002	3	5
LIVER	FGD4 →	+1.570	+0.280	.003	.002	3	4
SKIN	RPSA →	-0.623	-0.258	.001	<.001	3	4
BLOOD_Myeloma	MYO6 →	+2.392	+0.224	.002	.004	3	4
BREAST	GDPD3 →	+1.583	+0.152	.001	.005	3	4
SOFT_TISSUE	EPHB3 →	+2.203	+0.211	.008	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCF2L by Negative regulation of cytoskeleton organization activity — LIVER

Explore this box plot interactively →