Negative regulation of cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLD4, EEPD1, and PDLIM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytoskeleton organization activity versus POLD4 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	POLD4 →	+1.860	+0.440	.006	.001	3	6
OESOPHAGUS	EEPD1 →	+1.669	+0.254	<.001	<.001	3	5
BLOOD_Leukemia	PDLIM2 →	+1.707	+0.181	.001	<.001	3	5
LUNG_NSCLC_LUSC	RAP1A →	+0.952	+0.350	<.001	<.001	3	5
BLOOD_Leukemia	RHOG →	+0.909	+0.150	.003	.004	3	5
SKIN	PTTG1IP →	+0.779	+0.189	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051494 vs POLD4 — LUNG_NSCLC_LUSC

Explore this scatter interactively →