Positive regulation of filopodium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3, FSCN1, and KATNAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of filopodium assembly activity versus AKT3 in URINARY_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AKT3 →	+1.969	+0.392	.007	<.001	3	6
STOMACH	FSCN1 →	+3.694	+0.408	<.001	<.001	3	6
LIVER	KATNAL1 →	+1.457	+0.236	<.001	.007	2	6
URINARY_TRACT	FYN →	+1.676	+0.458	.006	.005	3	5
URINARY_TRACT	TUBA1A →	+3.350	+0.519	.008	.002	3	5
LUNG_SCLC	OXSM →	-0.447	-0.176	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051491 vs AKT3 — URINARY_TRACT

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