Negative regulation of filopodium assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of filopodium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP44, ARHGAP44_S596, and ANO10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of filopodium assembly activity versus ARHGAP44 in PDAC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ARHGAP44 →	+0.680	+0.055	<.001	<.001	3	7
LSCC	ARHGAP44_S596 →	+1.189	+0.070	<.001	<.001	3	5
GBM	ANO10 →	+0.322	+0.073	.001	.001	3	5
PDAC	TLN1_S2040 →	+0.610	+0.034	<.001	.001	3	4
LUAD	RUFY1_S165 →	+0.407	+0.054	.002	<.001	3	4
COAD	SELENBP1 →	+0.842	+0.041	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051490 vs ARHGAP44 — PDAC

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