Negative regulation of filopodium assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNL1, CFLAR-AS1, and EZH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of filopodium assembly activity versus KNL1 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KNL1 →	-0.799	-0.767	<.001	.001	3	5
CCRCC	CFLAR-AS1 →	+0.369	+0.477	<.001	.001	2	5
LSCC	EZH2 →	-0.925	-0.566	<.001	.005	3	4
LSCC	KIFC1 →	-0.784	-0.668	.002	.005	3	4
GBM	KIF4A →	-0.758	-0.246	.001	.002	3	4
PDAC	MYBPC3 →	+0.544	+0.538	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051490 vs KNL1 — LSCC

Explore this scatter interactively →