Regulation of filopodium assembly

Across TCGA patient cohorts, RNA activity of the Regulation of filopodium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZAP70, TESPA1_S311, and CELF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of filopodium assembly activity versus ZAP70 in UCEC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZAP70 →	+0.607	+0.060	<.001	<.001	3	7
GBM	TESPA1_S311 →	+0.748	+0.052	<.001	<.001	3	7
UCEC	CELF2 →	+0.455	+0.059	<.001	<.001	3	7
HNSC	DNAJB1 →	-0.272	-0.039	.001	.008	3	7
BRCA	LIMD2 →	+0.635	+0.042	<.001	<.001	3	7
LSCC	DOCK2 →	+0.540	+0.052	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051489 vs ZAP70 — UCEC

Explore this scatter interactively →