Regulation of filopodium assembly

Across TCGA cell cohorts, RNA activity of the Regulation of filopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM70, ATL3, and WNT10B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of filopodium assembly activity versus TMEM70 in OESOPHAGUS (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM70 →	-0.634	-0.216	.002	<.001	3	5
OESOPHAGUS	ATL3 →	+0.996	+0.156	.003	.009	3	4
PANCREAS	WNT10B →	-0.885	-0.352	.002	<.001	3	4
BLOOD_Leukemia	RPL22L1 →	-1.177	-0.569	.001	.008	3	4
OESOPHAGUS	CHRD →	-0.963	-0.160	.003	<.001	3	4
KIDNEY	HOXB8 →	-1.505	-0.220	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051489 vs TMEM70 — OESOPHAGUS

Explore this scatter interactively →