Regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of cytosolic calcium ion concentration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCGN, NPHP4, and SHLD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCGN grouped by Regulation of cytosolic calcium ion concentration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGN →	-0.336	-1.072	<.001	<.001	3	6
LARGE_INTESTINE	NPHP4 →	-0.255	-0.895	.001	.008	3	6
STOMACH	SHLD2 →	-0.200	-0.686	.009	.005	3	5
STOMACH	TRIM24 →	-0.148	-1.082	.004	.002	3	5
LARGE_INTESTINE	P2RX1 →	-0.337	-0.251	<.001	.001	2	6
UPPER_AERODIGESTIVE_TRACT	SLIT2 →	-0.176	-0.186	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCGN by Regulation of cytosolic calcium ion concentration activity — CNS

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