Regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, RUNX1, and APOL6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytosolic calcium ion concentration activity versus PSMB9 in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMB9 →	+2.370	+0.238	.002	.001	3	6
LUNG_SCLC	RUNX1 →	+2.159	+0.203	.002	.004	3	6
LIVER	APOL6 →	+2.210	+0.403	.001	.001	3	5
SKIN	PSME2 →	+0.766	+0.317	.003	<.001	3	5
LUNG_SCLC	TAGLN2 →	+2.651	+0.203	<.001	.006	2	6
BREAST	FPGS →	+0.671	+0.185	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051480 vs PSMB9 — LUNG_SCLC

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