Regulation of corticotropin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of corticotropin secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAUR, DYSF, and SEC62, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of corticotropin secretion activity versus PLAUR in LUAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLAUR →	+0.362	+0.050	.003	.001	3	5
PDAC	DYSF →	+0.244	+0.034	.005	.005	3	4
HNSC	SEC62 →	+0.197	+0.096	.003	.004	3	4
BRCA	ESYT2 →	+0.262	+0.058	.003	<.001	3	4
OV	CTPS2_S568 →	+0.806	+0.079	.002	.005	3	4
PDAC	STX8 →	+0.227	+0.062	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051459 vs PLAUR — LUAD

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