Corticotropin secretion

pathway activity — cross-omics
GO:0051458Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Corticotropin secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTND4LP13, IGFL2-AS1, and CXCL14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVMTND4LP13 →+0.720+0.054.002.00533
LUADIGFL2-AS1 →-0.479-0.091.001.00633
LSCCCXCL14 →-2.040-0.829.001<.00132
LSCCIGLV5-48 →+1.891+0.908.006.00332
OVIGLJ2 →+2.425+0.054<.001.00532
LSCCRPL26P28 →-0.650-0.655.005.00632
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration