Intracellular pH elevation

Across TCGA patient cohorts, RNA activity of the Intracellular pH elevation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSL1D1, LARS1, and MRPL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH elevation activity versus RSL1D1 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RSL1D1 →	+0.331	+0.068	.006	.009	3	5
COAD	LARS1 →	+0.214	+0.062	.002	.002	3	5
COAD	MRPL1 →	+0.438	+0.077	<.001	<.001	3	5
COAD	MRPL17 →	+0.262	+0.049	<.001	<.001	3	5
BRCA	MRPL47 →	+0.370	+0.088	<.001	.002	3	5
PDAC	MRPS30 →	+0.254	+0.086	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051454 vs RSL1D1 — GBM

Explore this scatter interactively →