Intracellular pH elevation

Across TCGA patient cohorts, RNA activity of the Intracellular pH elevation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PATL1, STX19, and RIMS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH elevation activity versus PATL1 in PDAC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PATL1 →	-0.439	-0.559	.001	.005	3	3
PDAC	STX19 →	+0.503	+0.641	.007	.006	3	3
PDAC	RIMS1 →	+0.349	+0.734	.001	<.001	3	3
OV	AVL9 →	-0.494	-0.476	.002	.004	3	2
OV	EIF3B →	-0.390	-0.583	.006	.001	3	2
OV	FAM184A →	-0.658	-0.598	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051454 vs PATL1 — PDAC

Explore this scatter interactively →