Intracellular pH elevation

Across TCGA cell cohorts, RNA activity of the Intracellular pH elevation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEBP1, NAGPA, and DTNBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEBP1 grouped by Intracellular pH elevation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PEBP1 →	-0.678	-1.435	.003	<.001	3	4
LIVER	NAGPA →	-0.810	-0.957	.001	.008	3	4
CNS	DTNBP1 →	-0.450	-0.844	.001	.003	3	4
OVARY	RAB11FIP3 →	-0.711	-0.953	.001	<.001	3	4
SKIN	EGF →	+1.336	+0.738	.001	.009	3	3
SKIN	CAMK2D →	+1.100	+0.866	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEBP1 by Intracellular pH elevation activity — LARGE_INTESTINE

Explore this box plot interactively →