Intracellular pH reduction

Across TCGA patient cohorts, RNA activity of the Intracellular pH reduction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC9A7_S693, TNS3_S762, and CEP170_S881, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH reduction activity versus SLC9A7_S693 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC9A7_S693 →	+0.966	+0.033	<.001	.006	3	5
HNSC	TNS3_S762 →	+0.715	+0.075	<.001	<.001	3	5
COAD	CEP170_S881 →	+0.527	+0.022	<.001	<.001	3	5
UCEC	HIP1 →	+0.304	+0.044	<.001	<.001	3	5
GBM	MAPKAPK2 →	+0.223	+0.038	.002	.006	3	5
GBM	NEK7 →	+0.337	+0.049	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051452 vs SLC9A7_S693 — LSCC

Explore this scatter interactively →