Intracellular pH reduction

Across TCGA patient cohorts, RNA activity of the Intracellular pH reduction pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB1P41, ZNF728, and NDRG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH reduction activity versus HMGB1P41 in OV (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HMGB1P41 →	-0.501	-0.184	<.001	.001	3	4
OV	ZNF728 →	-1.082	-0.245	.002	.002	3	4
CCRCC	NDRG2 →	-0.716	-0.144	<.001	.002	3	4
PDAC	PLXNA2 →	-0.609	-0.232	<.001	<.001	3	4
BRCA	TMOD1 →	-0.473	-0.130	.001	.003	3	4
CCRCC	ZNF594 →	-0.403	-0.147	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051452 vs HMGB1P41 — OV

Explore this scatter interactively →