Intracellular pH reduction

Across TCGA patient cohorts, RNA activity of the Intracellular pH reduction pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A7_S403, CLN6_S31, and RETREG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH reduction activity versus SLC4A7_S403 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A7_S403 →	+0.791	+0.267	<.001	<.001	3	5
BRCA	CLN6_S31 →	+1.268	+0.268	<.001	<.001	3	5
PDAC	RETREG3 →	+0.518	+0.293	<.001	<.001	3	4
PDAC	SACM1L →	+0.431	+0.270	<.001	<.001	2	5
UCEC	SAMM50 →	+0.490	+0.195	.004	.008	2	5
HNSC	SLC4A7 →	+0.465	+0.247	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051452 vs SLC4A7_S403 — PDAC

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