Intracellular pH reduction

Across TCGA cell cohorts, RNA activity of the Intracellular pH reduction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6AP1, ATP6V0C, and LAMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH reduction activity versus ATP6AP1 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP6AP1 →	+1.053	+0.204	<.001	.002	3	8
PANCREAS	ATP6V0C →	+0.979	+0.294	<.001	<.001	3	8
CNS	LAMP2 →	+1.713	+0.342	<.001	<.001	3	6
SKIN	GNPTG →	+1.039	+0.409	<.001	<.001	3	6
STOMACH	GBA →	+1.418	+0.284	.001	<.001	3	6
LIVER	SSR4 →	+1.230	+0.349	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051452 vs ATP6AP1 — LARGE_INTESTINE

Explore this scatter interactively →