Intracellular pH reduction

Across TCGA cell cohorts, RNA activity of the Intracellular pH reduction pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP6AP1, LAMP2, and ATP6V0D1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular pH reduction activity versus ATP6AP1 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP6AP1 →	+0.911	+0.269	<.001	<.001	3	14
LARGE_INTESTINE	LAMP2 →	+1.530	+0.290	<.001	<.001	3	14
LIVER	ATP6V0D1 →	+1.205	+0.317	.005	.007	2	14
BONE	ATP6V0A1 →	+1.464	+0.323	<.001	<.001	3	13
SOFT_TISSUE	MLEC →	+1.113	+0.245	.001	.001	3	10
STOMACH	CCT5 →	-1.288	-0.237	.002	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051452 vs ATP6AP1 — LARGE_INTESTINE

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