Myoblast proliferation

Across TCGA patient cohorts, RNA activity of the Myoblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKP1_T131, LCP1, and NCF4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast proliferation activity versus SKP1_T131 in COAD (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKP1_T131 →	-0.520	-0.037	.001	.002	3	7
OV	LCP1 →	+0.426	+0.049	.009	.002	3	7
LUAD	NCF4 →	+0.364	+0.045	<.001	<.001	3	7
OV	DOCK11 →	+0.506	+0.067	<.001	<.001	3	6
GBM	FES →	+0.439	+0.053	<.001	.002	3	6
LUAD	PLEKHO2 →	+0.260	+0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051450 vs SKP1_T131 — COAD

Explore this scatter interactively →