Negative regulation of meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Negative regulation of meiotic cell cycle pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OBI1_S210, RRM2, and TRIP13, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of meiotic cell cycle activity versus OBI1_S210 in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OBI1_S210 →	+0.805	+0.101	<.001	<.001	3	7
LUAD	RRM2 →	+0.763	+0.085	<.001	<.001	3	7
LUAD	TRIP13 →	+0.681	+0.064	<.001	<.001	3	7
LUAD	WDHD1 →	+0.735	+0.082	<.001	<.001	3	7
LUAD	ESF1_S153 →	+1.017	+0.066	<.001	<.001	3	7
LUAD	H1-4_T18 →	+1.398	+0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051447 vs OBI1_S210 — GBM

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