Negative regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT5, TRIP13, and TMPRSS4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of meiotic cell cycle activity versus CCT5 in LUNG_NSCLC_LUAD (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCT5 →	+0.876	+0.547	<.001	<.001	3	7
LUNG_NSCLC_LUAD	TRIP13 →	+0.992	+0.547	.008	<.001	3	6
PANCREAS	TMPRSS4 →	+4.446	+0.343	.006	.004	3	4
LUNG_NSCLC_LUAD	BRD9 →	+0.918	+0.547	.001	<.001	3	4
PANCREAS	FUT3 →	+4.280	+0.343	<.001	.004	3	3
PANCREAS	ISG20 →	+1.396	+0.343	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051447 vs CCT5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →