Positive regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM106B, NT5C1B, and PHKB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of meiotic cell cycle activity versus TMEM106B in SKIN (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM106B →	+1.034	+1.453	.007	<.001	3	4
BREAST	NT5C1B →	+0.231	+1.536	<.001	<.001	3	3
BLOOD_Myeloma	PHKB →	+1.064	+1.463	.002	.001	3	3
BLOOD_Myeloma	XPO5 →	+0.789	+1.601	.005	.007	3	3
BLOOD_Myeloma	ACSL1 →	+1.526	+1.510	<.001	<.001	3	3
LUNG_NSCLC_LUAD	DNAJA2 →	+0.396	+0.757	.005	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051446 vs TMEM106B — SKIN

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