Regulation of meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Regulation of meiotic cell cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC1, ANAPC5, and MTHFSD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC1 grouped by Regulation of meiotic cell cycle-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ANAPC1 →	-0.522	-0.222	<.001	.007	3	9
SKIN	ANAPC5 →	-0.415	-0.252	<.001	<.001	2	8
STOMACH	MTHFSD →	+0.368	+0.291	<.001	<.001	3	6
URINARY_TRACT	CDC27 →	-0.438	-0.155	<.001	.002	2	7
SOFT_TISSUE	NF2 →	+0.151	+0.206	.002	.002	3	5
LUNG_NSCLC_LUAD	UBE2S →	-0.215	-0.193	.006	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC1 by Regulation of meiotic cell cycle activity — LIVER

Explore this box plot interactively →