Negative regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM9, ASF1A, and SETD5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCM9 grouped by Negative regulation of ubiquitin-protein transferase activity-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MCM9 →	-0.860	-0.324	<.001	.003	3	6
SKIN	ASF1A →	-0.930	-0.202	<.001	<.001	3	5
PANCREAS	SETD5 →	-1.066	-0.227	.004	<.001	3	5
LARGE_INTESTINE	RPRD1A →	-0.835	-0.218	.008	.004	3	4
STOMACH	GSR →	-1.341	-0.189	<.001	<.001	3	4
LARGE_INTESTINE	BEND3 →	-0.688	-0.161	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCM9 by Negative regulation of ubiquitin-protein transferase activity activity — BLOOD_Myeloma

Explore this box plot interactively →