Negative regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO5, NUP43, and GTF3C4, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-protein transferase activity activity versus FBXO5 in SOFT_TISSUE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FBXO5 →	+1.243	+0.170	<.001	<.001	3	17
BREAST	NUP43 →	+0.622	+0.119	<.001	.002	3	16
BONE	GTF3C4 →	+0.964	+0.218	<.001	<.001	3	15
PANCREAS	POLE3 →	+1.030	+0.135	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	ZNF367 →	+1.229	+0.144	<.001	<.001	3	14
LARGE_INTESTINE	STAG1 →	+0.615	+0.091	<.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051444 vs FBXO5 — SOFT_TISSUE

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