Negative regulation of ubiquitin-protein transferase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-protein transferase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2D6, PIM2, and ELL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-protein transferase activity activity versus CYP2D6 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYP2D6 →	+1.008	+0.645	.002	.008	3	2
BLOOD_Leukemia	PIM2 →	-1.709	-0.447	<.001	.006	3	2
BLOOD_Lymphoma	ELL →	-1.257	-0.409	.004	.004	3	2
BLOOD_Leukemia	FYN →	+2.684	+0.650	.002	.008	3	2
BLOOD_Leukemia	TMBIM1 →	-1.618	-0.493	.003	.002	3	2
BLOOD_Leukemia	NEK3 →	-1.961	-0.483	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051444 vs CYP2D6 — BLOOD_Leukemia

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