Response to cortisol

Across TCGA patient cohorts, RNA activity of the Response to cortisol pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCN, DPT, and LUM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cortisol activity versus DCN in CCRCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DCN →	+1.006	+0.072	<.001	<.001	3	9
CCRCC	DPT →	+0.741	+0.076	.001	.001	3	9
BRCA	LUM →	+0.774	+0.050	<.001	<.001	3	9
CCRCC	CYP1B1 →	+0.905	+0.083	<.001	<.001	3	9
UCEC	BGN →	+0.814	+0.105	<.001	<.001	3	9
CCRCC	EFEMP1 →	+0.858	+0.088	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051414 vs DCN — CCRCC

Explore this scatter interactively →