Response to cortisol

Across TCGA patient cohorts, RNA activity of the Response to cortisol pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGIS, IGFBP7, and BNC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cortisol activity versus PTGIS in LSCC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTGIS →	+0.638	+0.183	.009	.005	3	6
GBM	IGFBP7 →	+0.624	+0.140	<.001	.001	3	6
PDAC	BNC2 →	+0.545	+0.251	<.001	<.001	3	6
PDAC	FBLN1 →	+0.809	+0.257	<.001	<.001	3	6
PDAC	PRICKLE1 →	+0.592	+0.148	<.001	<.001	3	6
HNSC	PLA2G5 →	+0.408	+0.163	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051414 vs PTGIS — LSCC

Explore this scatter interactively →