Response to cortisol

Across TCGA cell cohorts, RNA activity of the Response to cortisol pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3IP1, RLN1, and PARD6B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIK3IP1 grouped by Response to cortisol-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIK3IP1 →	-2.562	-1.742	.003	<.001	3	3
URINARY_TRACT	RLN1 →	-0.676	-1.271	.004	.004	3	3
URINARY_TRACT	PARD6B →	-1.360	-1.571	.001	.004	3	3
BLOOD_Lymphoma	NIPA1 →	-2.670	-1.431	.006	.007	3	3
STOMACH	FERMT2 →	-2.674	-0.500	.002	.008	3	3
BLOOD_Myeloma	ETNK2 →	-0.197	-1.183	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIK3IP1 by Response to cortisol activity — URINARY_TRACT

Explore this box plot interactively →