Response to cortisol

Across TCGA cell cohorts, RNA activity of the Response to cortisol pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are P22077, Dyrk1b_0191, and JQ1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P22077 grouped by Response to cortisol-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	P22077 →	-0.443	-1.545	.031	.024	3	2
OVARY	Dyrk1b_0191 →	+0.490	+0.124	.021	.034	3	1
BONE	JQ1 →	+0.806	+1.545	.015	.024	3	1
BONE	CAP-232 →	-0.896	-1.545	.007	.024	3	1
BONE	KU-60019 →	+0.639	+1.669	.032	.049	2	1
BONE	PRT062607 →	-0.495	-2.038	.041	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P22077 by Response to cortisol activity — BONE

Explore this box plot interactively →