Response to corticosterone

Across TCGA patient cohorts, RNA activity of the Response to corticosterone pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL_S487, MARCKS_S101, and ELF1_S333, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosterone activity versus COIL_S487 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	COIL_S487 →	+0.706	+0.145	<.001	<.001	3	7
LSCC	MARCKS_S101 →	+0.575	+0.112	<.001	<.001	3	7
LUAD	ELF1_S333 →	+0.605	+0.129	<.001	<.001	3	7
LUAD	CAST_S577 →	+0.849	+0.121	<.001	<.001	3	6
HNSC	UBAP1_S146 →	+0.519	+0.092	.001	.007	3	6
LSCC	CALD1_S789 →	+0.925	+0.109	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051412 vs COIL_S487 — HNSC

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