Response to corticosterone

Across TCGA patient cohorts, RNA activity of the Response to corticosterone pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEFL, RPL39P29, and GLP2R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosterone activity versus NEFL in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NEFL →	+2.425	+1.006	<.001	<.001	3	4
PDAC	RPL39P29 →	+0.452	+0.459	.003	.003	2	5
GBM	GLP2R →	+0.437	+0.920	.001	<.001	3	4
UCEC	MOCS3 →	-0.374	-0.700	<.001	.001	3	3
UCEC	PINX1 →	-0.308	-0.641	.008	.003	3	3
GBM	PPP1R16B →	+1.359	+1.076	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051412 vs NEFL — CCRCC

Explore this scatter interactively →