Response to corticosterone

Across TCGA cell cohorts, RNA activity of the Response to corticosterone pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED29, FOXA1, and ITGB1BP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED29 grouped by Response to corticosterone-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MED29 →	-0.843	-1.165	<.001	<.001	3	3
URINARY_TRACT	FOXA1 →	+4.386	+1.769	.006	<.001	2	4
URINARY_TRACT	ITGB1BP2 →	+1.446	+1.795	.008	<.001	3	3
URINARY_TRACT	LRRC8D →	-1.038	-1.189	.001	.004	2	4
URINARY_TRACT	KLF11 →	-2.576	-1.776	.002	<.001	3	3
URINARY_TRACT	RPH3AL →	+2.603	+1.618	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED29 by Response to corticosterone activity — OVARY

Explore this box plot interactively →