Response to corticosterone

Across TCGA cell cohorts, RNA activity of the Response to corticosterone pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRN3P1, DDX23, and HSD11B2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRN3P1 grouped by Response to corticosterone-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RRN3P1 →	+0.430	+1.580	.007	.003	3	2
LARGE_INTESTINE	DDX23 →	+0.566	+1.580	.001	.003	3	1
LARGE_INTESTINE	HSD11B2 →	-0.233	-1.580	<.001	.003	3	1
LARGE_INTESTINE	DIRAS1 →	+0.113	+1.580	.003	.003	3	1
LARGE_INTESTINE	MAGEB18 →	+0.140	+1.580	<.001	.003	3	1
LARGE_INTESTINE	CSTF2T →	+0.213	+1.580	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRN3P1 by Response to corticosterone activity — LARGE_INTESTINE

Explore this box plot interactively →