Detoxification of nitrogen compound

Across TCGA patient cohorts, RNA activity of the Detoxification of nitrogen compound pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSTM3, GSTM2, and CASP4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of nitrogen compound activity versus GSTM3 in LSCC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GSTM3 →	+1.489	+0.134	<.001	<.001	3	9
LSCC	GSTM2 →	+0.971	+0.112	<.001	<.001	3	8
GBM	CASP4 →	-0.458	-0.063	.001	.007	3	7
GBM	SAMSN1 →	-0.465	-0.063	<.001	<.001	3	6
LSCC	UNC13D →	-0.482	-0.072	<.001	<.001	3	6
BRCA	C1orf226_S223 →	+0.900	+0.107	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051410 vs GSTM3 — LSCC

Explore this scatter interactively →