Detoxification of nitrogen compound

Across TCGA cell cohorts, RNA activity of the Detoxification of nitrogen compound pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD52, SEPTIN10, and MIDEAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD52 grouped by Detoxification of nitrogen compound-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ANKRD52 →	+1.074	+1.537	.001	.001	3	5
LARGE_INTESTINE	SEPTIN10 →	-0.679	-1.071	.001	.002	3	4
SOFT_TISSUE	MIDEAS →	+0.918	+0.901	.003	.002	3	4
SOFT_TISSUE	HSBP1 →	+1.151	+1.178	<.001	.005	3	4
BONE	CCDC186 →	+0.623	+1.537	.002	.001	3	4
OVARY	PHACTR4 →	+1.138	+1.146	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD52 by Detoxification of nitrogen compound activity — BONE

Explore this box plot interactively →