Detoxification of nitrogen compound

Across TCGA cell cohorts, RNA activity of the Detoxification of nitrogen compound pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB2, STEAP1, and CARF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification of nitrogen compound activity versus MSRB2 in OESOPHAGUS (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MSRB2 →	+1.410	+1.043	.006	.009	3	4
BONE	STEAP1 →	+4.065	+1.811	.003	<.001	3	4
OESOPHAGUS	CARF →	+1.232	+1.519	.007	<.001	3	4
OESOPHAGUS	GOLGA1 →	+1.222	+1.490	.001	<.001	3	4
LIVER	PPP1R16A →	+1.705	+2.024	.001	.004	2	4
OVARY	CD34 →	-1.500	-1.684	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051410 vs MSRB2 — OESOPHAGUS

Explore this scatter interactively →