Response to nitrosative stress

Across TCGA patient cohorts, RNA activity of the Response to nitrosative stress pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, SNX20, and LILRB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nitrosative stress activity versus MAP4K1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAP4K1 →	+0.509	+0.099	.001	<.001	3	4
BRCA	SNX20 →	+0.812	+0.129	<.001	.002	3	4
BRCA	LILRB1 →	+0.761	+0.130	<.001	.001	3	4
BRCA	IRAG2 →	+0.498	+0.122	.001	.002	3	4
BRCA	CD72 →	+0.738	+0.133	<.001	<.001	3	4
BRCA	LINC00426 →	+0.278	+0.076	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051409 vs MAP4K1 — BRCA

Explore this scatter interactively →